Hypertension
Conditions
Brief summary
To study central blood pressure changes caused by commonly used high blood pressure medications in pregnancy.
Detailed description
Central blood pressures in addition to pulse wave velocity will be attained prior to medication, and then every 30 minutes for 4 hours (total of 9 readings). Sphygmomanometer readings will be completed at the same time (total readings 9). These readings are all related to the study. Nursing will have the opportunity to to record the routine sphygmomanometer readings for their routine vitals if they chose to do so. Their participation will be complete after the 4 hour assessment is complete.
Interventions
OTHERNifedipine
patients will be assigned to antihypertensive medications by their physicians in the course of their routine care
OTHERLabetalol
patients will be assigned to antihypertensive medications by their physicians in the course of their routine care
Sponsors
St. Louis University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
14 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Singleton pregnancy * Women with hypertensive disease in pregnancy who are currently being treated with nifedipine xl or labetalol
Exclusion criteria
* Multiple pregnancy * Currently on multiple anti-hypertension medications * Narcotic use * Irregular heart rhythms or arrhythmias * Peripheral arterial disease, leg artery disease * Reynaud's phenomena * Intense cold/hypothermia * If there is a wound at location of where central arterial cuff would be placed or tonometer for carotid assessment * Known sensitivity to labetalol or nifedipine * Severe tachycardia (\>120) * Greater than 1st degree heart block * Severe asthma * Congestive heart failure or heart disease * Lupus * Inability to adequately monitor BP * Currently receiving magnesium sulfate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| central blood pressure changes | every 30 min for 4 hours |
Outcome results
None listed