Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02912520

Enrollment

Registered

2016-09-23

Start date

2016-06-30

Completion date

2017-04-23

Last updated

2017-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immunoglobulin A

Brief summary

Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and without antibiotic therapy in order to detect significant differences.

Interventions

DRUGAnti-Bacterial Agents

administration of any antibiotic substance(s) over the course of 2 weeks

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* endotracheal intubation * antibiotic therapy for 2 weeks OR no antibiotic therapy for at least 3 months

Exclusion criteria

* active infection * pregnancy * immunodeficiency

Design outcomes

Primary

Measure	Time frame
IgA levels in the bronchoalveolar lavage fluid	2 weeks of ICU stay

Secondary

Measure	Time frame
number of detected bacterial, viral, and fungal infections per patient	through study completion, an average of 2 months

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026