Chronic Arthritis
Conditions
Keywords
Biomarkers, Genetic, Chronic arthritis, Treatment
Brief summary
Use of genotyping for the optimization of treatment with biologics in chronic arthritis by looking for an association between certain alleles and response to treatment.
Detailed description
Chronic arthritis in children and in adults represent a public health problem in number and difficulty of treatment. 30% of patients are non-responders and / or relapse upon discontinuation of treatment. Some of these treatments are not always well tolerated, sometimes with infectious complications including tuberculosis limiting the use of biological therapies. This study will validate a battery of genetic markers to predict responders biotherapy, determine the prognosis of patients, these treatments are reserved for the most severe forms, and thus improve the care of patients.
Interventions
OTHERBlood sample
Conservation at the end of the blood sample
Sponsors
University Hospital, Montpellier
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Months to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients treated with biotherapy may be included in this study with all information necessary for regular medical consultations (filling specific monitoring by GPs questionnaires), physical therapists visits, occupational therapists, psychologists.. etc
Exclusion criteria
* Patients treated with biological therapy for non rheumatic disease * Other inflammatory diseases such as Crohn's disease * Refusal to participate in the collection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of responsive patients with a given polymorphism (%) | At the inclusion |
Secondary
| Measure | Time frame |
|---|---|
| Distribution of patients with a given biotherapy (%) | At the inclusion |
| Distribution of patients presenting a given polymorphism (%) | At the inclusion |
Outcome results
None listed