Ocular Melanoma
Conditions
Brief summary
This prospective, non-therapeutic study will determine whether a novel imaging technique can identify presumptive tumour associated macrophages (TAMs) in patients with ocular tumours. The investigators will evaluate 5 groups: 1. Choroidal nevus 2. Choroidal indeterminate melanocytic lesion 3. Choroidal melanoma 4. Suspected metastatic tumour (ie, primary tumour elsewhere) 5. Locally treated ocular tumours
Interventions
OTHERcSLO imaging
Sponsors
Unity Health Toronto
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Any tentative clinical diagnosis of: 1. Choroidal nevus (low-risk features): 2. Choroidal indeterminate melanocytic lesion (high-risk features) 3. Choroidal melanoma 4. Suspected metastatic tumour (ie, primary tumour elsewhere) 5. Locally treated ocular tumours Note that a patient can enroll in this study twice, once before treatment and once after, provided that at least one month has passed since initiation of treatment. This patient will count twice (ie, once in each of two study arms) Male and female age 18 years and older Ability to provide informed consent
Exclusion criteria
* Allergy to angiography dye * Cases that do not meet the above criteria for tumor size will be ineligible to participate in the study. * Patients not able to provide consent for the study. * Patients with a poor view of the fundus due to cataract or vitreous hemorrhage. * Patients \< 18 years of age. Any concurrent unrelated eye diagnosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of macrophages | 1 week |
Countries
Canada
Contacts
Primary ContactEmily Mathieu, PhD
Outcome results
None listed