Postoperative Cognitive Dysfunction
Conditions
Keywords
desflurane, sevoflurane
Brief summary
This study compares desflurane with sevoflurane for school-age children in postoperative cognitive function.
Detailed description
The postoperative cognitive dysfunction (POCD) of school-age children (6-14 age) after operation draw more attention from both society and family. It is well known that, compare with sevoflurane, desflurane could improve cognitive function in elderly patients. But whether Desflurane could improve postoperative cognitive function compare with Sevoflurane for the school-age children, there is no consistent conclusion.
Interventions
DRUGDesflurane
Anesthesia maintenance: After endotracheal intubation, half of the patients will be randomized into Desflurane Group. The gas flow rate of Desflurane group is 2 L/min, include 50％ O2 and 4～5％ Desflurane.
DRUGsevoflurane
Anesthesia maintenance: After endotracheal intubation, half of the patients will be randomized into Sevoflurane Group. The gas flow rate of Desflurane group is 2 L/min, 50％O2 and 1.7-2.0% Sevoflurane.
Sponsors
Shengjing Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
6 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
* 6-14 age, elective no-cardiac and non-neurological surgery , ASA physical statusⅠorⅡ, no preoperative cognitive function impairment, cooperate to complete the entire test.
Exclusion criteria
* Allergic to halogens inhaled anesthetics, malignant hyperthermia susceptible patients, intracranial hypertension, emotional disorder, hyperactivity, history of operation, mental retardation, audio-visual obstacles, history of congenital heart disease, Important organ dysfunction, history of drug abuse * History of epilepsy * Preoperative respiratory infection significantly.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of postoperative cognitive dysfunction | Within 7 days after operation | Cognitive function score should be carried out for all children at preoperative 1d, postoperative 2 d, 3d and 7d. If postoperative score compared with preoperative score drop 1 points or more, then postoperative cognitive dysfunction will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| male | 1 day before operation | If the child is boy,it's yes,or it's no. |
| height | 1 day before operation | CM |
| weight | preoperation | kg |
| previous operation history | preoperation | If the child had previous operation history,it's yes,or it's no. |
| the duration of anesthesia | From the time began to give the anesthetic to the time of pull out the endotracheal intubation | minutes |
| the duration of operation | Surgery end time minus the start time | minutes |
| age | 1 day before operation | years old |
| total volume of infusion | The total volume of infusion of the whole surgery time. | ml |
| whether there is respiratory depression in postanesthesia care unit | The period which the patient stay at post anesthesia care unit,from the time enter to postanesthesia care unit to the time leave postanesthesia care unit,the estimated period is up to 30 minutes. | If the child has respiratory depression during this time,it's yes,or it's no. |
| the length of hospital stay | the time from admission to hospital to discharge from hospital,the estimated period is up to 5 days. | days |
| S100β | 1 day after surgery | obtain the children's plasma to detection S100β with ELEASE. |
| NSE | 1 day after surgery | obtain the children's plasma to detection NSE with ELEASE. |
| total blood loss | The total blood loss of the whole surgery time. | ml |
Contacts
Primary ContactYingjie Du, MD
Outcome results
None listed