CD34 Selected Peripheral Blood Stem Cell Graft
Conditions
Keywords
PET/CT, MRI, Assess Thymic Function, 16-1244
Brief summary
The purpose of this study is to see if a positron emission tomography/computed tomography (PET/CT) scan and a magnetic resonance imaging (MRI) of the chest can assess changes in the thymus size and function. The researchers would like to monitor the thymus with a PET/CT scan and a MRI before and after the participants transplantation.
Interventions
DEVICEPET/CT scans
DEVICEMRI
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patient's age is ≥18 or ≤65 years old. * Patients must have a plan to receive a CD34-selected peripheral blood stem cell graft.
Exclusion criteria
* Patient is not able to undergo MR imaging due to any contraindication to MRI based on departmental MR questionnaire (e.g. past gadolinium allergies, failure of metallic screening, claustrophobia, inability to lay flat for duration of the study, inability to hold breath, etc.) * Pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in thymic size | 1 year | A clinically meaningful change is defined as increase in thymic size (\> 0.2cm increase in uni-dimensional diameter), functional volume (\>10%) or uptake (≥25%). We will report proportion of patients with each component of clinically meaningful change, as well as the proportion with at least one component, along 95% exact confidence intervals. |
Countries
United States
Outcome results
None listed