Effectiveness of Ultrasound Guided Corticoanesthetic Injection in Carpal Tunnel Syndrome

Effectiveness of Ultrasound Guided Corticoanesthetic Injection in Carpal Tunnel Syndrome Comparing Two Different Injection Sites

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02907671

Enrollment

Registered

2016-09-20

Start date

2016-10-31

Completion date

2018-12-31

Last updated

2018-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal Tunnel Syndrome

Keywords

carpal tunnel injection, corticosteroid, ultrasound-guided, musculoskeletal ultrasound

Brief summary

Effectiveness of ultrasound guided corticoanesthetic injection in carpal tunnel syndrome treatment comparing two different injection sites. Single-blind randomized trial.

Detailed description

Carpal tunnel syndrome (CTS) is the most common nerve entrapment neuropathy. Six placebo-controlled trials with 393 participants proved corticosteroid injection to be effective in symptom relief. However, all injections were palpation-guided. Therefore, the exact injection site was uncertain. Although three studies comparing palpation and ultrasound (US) guided CTS injection showed US superiority, the optimal injection site for the injectate delivery remains unclear. Some authors believe in thinning of the flexor tenosynovium as the mechanism of the median nerve decompression, and therefore recommend injection between the tendons, away from the nerve. Other authors stress the importance of hydrodissection and direct contact of the injectate with the nerve and suggest injection targeting the median nerve. According to our best knowledge, no study comparing different injection sites for a corticosteroid delivery in CTS has been published in English written literature. The objective of this study was to determine the optimal target site for the corticosteroid delivery in CTS injection.

Interventions

PROCEDUREcarpal tunnel corticoanesthetic injection

Different Injection Sites (between the flexot tendons or around the median nerve with hydrodissection)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* primary idiopathic CTS * symptoms of classic or probable CTS (numbness or tingling in at least 2 of the 4 radial fingers) * unsuccessful 1-month treatment with wrist splinting * nerve conduction test results that showed median neuropathy at the wrist

Exclusion criteria

* previous steroid injection * diabetes mellitus, * thyroid disorder * inflammatory disease * polyneuropathy * current pregnancy * previous carpal tunnel surgery * severe illness * inability to respond to questionnaires

Design outcomes

Primary

Measure	Time frame	Description
Visual analogue scale	up to 1 year	pain severity scale

Secondary

Measure	Time frame	Description
Michigan Hand Outcomes Measure	up to 1 year	Hand function status
Boston carpal tunnel questionnaire	up to 1 year	Hand function status
Procedural CAS	up to 1 year	discomfort during the internetion

Countries

Czechia

Contacts

Primary ContactKamal Mezian, M.D.

kamal.mezian@gmail.com00420603313207

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026