Vitamin D and HbA1c Levels in Diabetic Patients With CKD

Association Between Serum 25-hydroxyvitamin D Levels and Glycated Haemoglobin in Diabetic Patients With Chronic Kidney Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02906319

Enrollment

100

Registered

2016-09-20

Start date

2015-09-30

Completion date

2016-07-31

Last updated

2016-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Vitamin D Deficiency

Brief summary

The purpose of this study is to determine the association between serum 25-hydroxyvitamin D and HbA1c levels in diabetic patients with chronic kidney disease. The investigators hypothesized that serum 25-hydroxyvitamin D levels were negatively correlated with HbA1c levels.

Detailed description

This was a cross sectional study using consecutive sampling methodology for participant recruitment. It was carried out at the specialized diabetic, renal, and general outpatient clinics in the University of Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia. Serum 25(OH)D levels were determined by using direct chemiluminesent immunoassay (ADVIA Centaur XP; Siemens Healthcare Diagnostics, Tarrytown, New York, USA). Serum HbA1c levels were determined using high-pressure liquid chromatography (Variant™ II Turbo; Bio-Rad, Hercules, California, USA). Data collected will be analyzed using Statistical Package for Social Sciences SPSS version 23.0 for Windows, version 23.0 (IBM Corp., Armonk, New York, USA).

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* eGFR 15-59 ml/min/1.73m2 * age ≥ 18 years old * able to provide informed consent

Exclusion criteria

* active infections * autoimmune diseases * malignancies * on immunosuppressive therapy * on vitamin D supplements

Design outcomes

Primary

Measure	Time frame	Description
25-hydroxyvitamin D levels	Within 2 weeks from enrolment	The unit of measure was nmol/L. The detection limit of the device was \<10 nmol/L. A mean value of 5 nmol/L were taken for results reported as \<10nmol/L.
HbA1c levels	Within 2 weeks from enrolment	The unit of measure was percentage (using NGSP standarization).

Outcome results