Relationship Between Gestational Diabetes Mellitus and Inflammatory Adipocytokins in Obese Mothers and Their Newborn at Delivery

Relation Entre diabète Gestationnel et Adipocytokines Inflammatoires Chez Des mères obèses et Leur Nouveau-né à l'Accouchement

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02905487

Acronym

ADIPOGEST

Enrollment

Registered

2016-09-19

Start date

2016-01-31

Completion date

2019-06-30

Last updated

2018-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, Gestational

Keywords

Gestational Diabetes Mellitus, Obesity, Adipocytokin

Brief summary

ADIPOGEST study aims at comparing circulating levels of inflammatory adipocytokins and C-reactive protein in obese women and their newborn at delivery whether exposed or not to Gestational Diabetes Mellitus (GDM)

Detailed description

ADIPOGEST is a cross sectional study in which mothers are divided into 2 groups : exposed and unexposed to GDM, matched on pregestational BMI, date of delivery and child gender. Mothers are recruited in the maternity ward of the University Hospital in South of Reunion Island. It is planned a conveniance sample of 20 mother-child pairs per group.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Pregnant women * Obese women (BMI : 30 kg/m² or more) * Aged over 18 years * With single pregnancy * With alive newborn at 37 weeks of amenorrhea or more * With informed consent

Exclusion criteria

* Smoker * Treatments by corticoïds or thyroid hormons * Overt diabetes * Complicated pregnancy * Premature delivery threat

Design outcomes

Primary

Measure	Time frame
Blood levels of leptin in mother and her child	2 years
Blood levels of adiponectin in mother and her child	2 years
Blood levels of IL-6 in mother and her child	2 years
Blood levels of TNF-alpha in mother and her child	2 years
Blood levels of C- Reactive Protein in mother and her child	2 years

Secondary

Measure	Time frame
Blood level of C-peptide in mother	2 years

Countries

France

Outcome results