Food Habits
Conditions
Brief summary
IBS is a global disease, patients often because of long-term symptoms of recurrent, not timely diagnosis and treatment effect is not ideal and frequent treatment, seriously affect the quality of life, and cause the corresponding economic and social burden.At present，a number of studies suggest that fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAPs) can induce IBS symptoms.Data from large randomized controlled trials are limited, leaving clinicians with the challenge of providing patients with reliable guidance based on minimal evidence.
Detailed description
IBS is a global disease, patients often because of long-term symptoms of recurrent, not timely diagnosis and treatment effect is not ideal and frequent treatment, seriously affect the quality of life, and cause the corresponding economic and social burden.At present，a number of studies suggest that fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAPs) can induce IBS symptoms.Data from large randomized controlled trials are limited, leaving clinicians with the challenge of providing patients with reliable guidance based on minimal evidence. This study will compare the effect of low FODMAPs diet and usual diet instruction on Intestinal flora, intestinal short chain fatty acids and quality of life by two groups.The results will answer the effect and long-term safety of Low FODMAPs diet.
Interventions
BEHAVIORALLow FODMAPs Diet
Instruct to design and eat Low Fermentable，Oligo-，Di-，Mono-saccharides And Polyols(FODMAPs) Diet
BEHAVIORALDiet instruction
Answer the doubt and help the patient get the diet knowlege about the IBS.
Sponsors
Jinsong Wang
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Diagnostic criteria for Rome Ⅲ * IBS patients with diarrhea type * By endoscopy, X-ray, B ultrasound and laboratory examination to exclude organic disease * Patients be able to communicate well with the researchers and be willing to participate in the study
Exclusion criteria
* Stomach, small intestine, colon surgery history * irritable bowel disease (IBD) active period, celiac disease * Alcoholics or drug abuse * Pregnant or lactating women * Recent drug users who use defecation * Have a special diet
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microbiota / Short chain fatty acids | Change from baseline Microbiota / Short chain fatty acids at 4 weeks | The fecal samples of IBS patients were analyzed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Irritable bowel syndrome severity scoring system scale | Baseline,1,and 3 month post randomization | Irritable bowel syndrome severity scoring system scale is an integral system for monitoring the severity of IBS in patients with disease severity.The scale is mainly from the degree of abdominal pain, abdominal pain frequency, abdominal distension, defecation satisfaction and the impact of life, according to the 10cm visual scoring method |
| The Short Form 36 (SF-36) scale | Baseline,1,and 3 month post randomization | SF-36 is a general scale, at present, the most commonly used evaluation of IBS. It includes 36 items, a total of 8 dimensions |
| Irritable bowel syndrome quality of life (IBS-QOL) scale | Baseline,1,and 3 month post randomization | Irritable bowel syndrome quality of life (IBS-QOL) scale is a more extensive application of the specific scale of IBS. |
| Satisfaction questionnaire | 1,and 3 month post randomization | To understand the patient's satisfaction with symptom control and diet guidance. The questionnaire included 3 items |
Countries
China
Contacts
Primary ContactTianqi Zhou, Dr.
Backup ContactYamei Gu, Dr.
Outcome results
None listed