Acute Stroke, TIA (Transient Ischemic Attack)
Conditions
Keywords
mobility, exercise, walking capacity, fat mass, muscles
Brief summary
Eighty community-living individuals in Uppsala municipality will be included. Intervention: Outdoor walking exercise program and one strength exercise. Methods: Clinical assessments, questionnaires and medical records. Assessment of motor function, cognition, level of physical activity, food intake and perceived stress are performed at screening as baseline measurements. Walking capacity, mobility, handgrip strength, body composition and cardiovascular risk markers will be assessed at baseline and after 12 week of training. At one year after training health-related quality of life, another cardiovascular incidence and mortality will be documented.
Detailed description
Eighty community-living individuals in Uppsala municipality will be included in a randomized controlled trial with two arms. Intervention: Participants will perform an outdoor walking exercise program together with one strength exercise for 12 weeks. The intensity and frequency of the training will progressively increase. Participants are supposed to walk and perform strength training 5-7 days/week. Methods: Clinical assessments, questionnaires and medical records used for documentation of age, sex, comorbidity, blood pressure, medications and previous education. Assessment of motor function, cognition, level of physical activity, food intake and perceived stress are performed at screening as baseline measurements. Walking capacity (primary outcome measure), mobility, handgrip strength, body composition and cardiovascular risk markers will be assessed at baseline and after 12 week of training. At one year after training health-related quality of life, another cardiovascular incidence and mortality will be evaluated. Power analysis is performed. The investigators will analyze the data using an intention-to -treat analysis. Participants should have participated in at least 50% of the training sessions
Interventions
OTHEROutdoor walking and strength exercise
Exercise group: Participants are supposed to perform an outdoor walking exercise program and one strength exercise for 12 weeks. The first 2 weeks start with daily walks. The intensity and frequency of walks will progressively increase performed according to the Borg scale: 12-15, ie, moderate to strenuous. Participants will walk 5-7 days/week. Added to this is a strength exercise, i.e. chair-rising which also should be performed daily.
OTHERcontrol group
Control-Group: Treatment as usual for 12 weeks, without restriction of being physically active.
Sponsors
Uppsala County Council, Sweden
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Verified ischemic cerebral infarction or intracerebral hemorrhage. 2. Sufficient walking capacity and motor function 3. Able to communicate in Swedish 4. Signed consent
Exclusion criteria
One or more of the following: 1. Subarachnoid bleeding 2. Insufficient cognition and impaired ability to understand instructions 3. Medical problems that make it unsuitable to participate 4. Pacemaker (body composition measurements)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 6 minute walk test (6MWT) | from baseline walking capacity to three months | walking capacity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 10 meter walk test (10mWT) | from baseline 10mWT to three months | gait speed |
| Hand-dynamometer (Jamar) | from baseline Jamar to three months | hand-grip strength |
| Body composition (bioelectric impedance analysis) | from baseline body composition to three months | muscles and fat mass and BMI |
| Cardiometabolic risk markers | from baseline cardiometabolic risk markers to three months | blood lipids, c-reactive proteins (CRP), blood glukos, HbA1c, Insulin-like growth factor (IGF-1), Interleukin-6 (Il-6) |
| Heart and lung foundation stress test | at baseline | self-perceived stress |
| Short Physical Performance Battery (SPPB) | from baseline SPPB to three months | mobility |
| Montreal outcome assessment (MoCA) | at baseline | cognition |
| Modified rankin scale (MRS) | at baseline | motor function |
| Mortality | from baseline to 1 year | register-based mortality |
| Health-related quality of life | from baseline to 1 year | register-based quality of life |
| Food frequency questionnaire | at baseline | self-reported food intake and quality |
Countries
Sweden
Contacts
Primary ContactBirgit Vahlberg, Med Dr, RPT
Backup ContactTommy Cederholm, Professor,MD
Outcome results
None listed