Critically Ill
Conditions
Keywords
plasma citrulline, lipopolysaccharide, critically ill, Hospitalization in an Intensive Care Unit
Brief summary
In critically ill patients, the small bowel permeability is increased, leading to bacterial translocation, and systemic inflammatory response syndrome. Plasma citrulline is a validated biomarker of functional enterocyte mass. Lipopolysaccharide (LPS) is a part of Gram negative bacteria, and plasma LPS concentration is a biomarker of bacterial translocation. The link between plasma citrulline and LPS in the critically ill is unknown. Investigators hypothesize that patients presenting with low plasma citrulline concentration, with presumed altered small bowel function, would have an increased phenomenon of bacterial translocation, and increased plasma LPS concentration. Investigators aimed to evaluate the link between plasma citrulline and LPS concentrations in critically ill patients at the time of ICU admission.
Interventions
Two blood samples will be taken at ICU admission
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Critically ill patients requiring ICU admission for at least 48 hours * Adults
Exclusion criteria
* Chronic small bowel disease * Chronic renal failure (clearance of creatinine \< 50 mL/min) * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma citrulline concentration | Up to 12 hours after admission in the unit | biological assay |
| plasma lipopolysaccharide concentration | Up to 12 hours after admission in the unit | biological assay |
Countries
France
Contacts
Primary ContactGaël Piton, MD, PhD
Outcome results
None listed