Obesity
Conditions
Brief summary
The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.
Interventions
DIETARY_SUPPLEMENTPlacebo
Tap water 200ml
DIETARY_SUPPLEMENTGlucose
25g Glucose in 200ml tap water
DIETARY_SUPPLEMENTMonosodium glutamate
1g monosodium glutamate in 200ml tap water
DIETARY_SUPPLEMENTQuinine
17mg quinine in 200ml tap water
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery * right handed
Exclusion criteria
* cardiovascular disease * neurologic/psychiatric disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of tastants on cerebral blood flow measured by functional brain MRI | changes from baseline to one hour after treatment |
Secondary
| Measure | Time frame |
|---|---|
| Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations | changes from baseline to one hour after treatment |
| Effect of tastants plasma ghrelin concentrations | changes from baseline to one hour after treatment |
Countries
Switzerland
Contacts
Primary ContactBettina Wölnerhanssen, Dr
Outcome results
None listed