Hypertension
Conditions
Keywords
Hypertension, Blood pressure, Hemostasis, Endothelial function
Brief summary
Randomized double-blind parallel group study in patients with mild-to-moderate hypertension to evaluate the effects beyond the blood pressure lowering effect of treatment for 12 weeks with ramipril or doxazosin on hemostatic mechanisms and on endothelial function.
Detailed description
This study aims to answer the following questions: 1) Does antihypertensive therapy with doxazosin exhibit antithrombotic effects in patients with essential hypertension? 2) Are the potential antithrombotic effects of doxazosin different to the effects of an ACE inhibitor? 3) Is there a relation between the antihypertensive effect and the antithrombotic effect of these antihypertensive agents? The co-primary outcomes are changes in endothelial function assessed by flow mediated vasodilatation, and in haemostatic function measured by the generation of thrombin-antithrombin complex.
Interventions
DRUGRamipril
Antihypertensive therapy
DRUGDoxazosin
Antihypertensive therapy
Sponsors
Karolinska Institutet
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Primary mild-to-moderate hypertension
Exclusion criteria
* Pregnancy and lactation * Recent (6 months) malignant disease or ongoing treatment for malignancy * No absolute indication or contraindication for any of the study drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thrombin generation | 12 weeks | Thrombin-Antithrombin complex (TAT) |
| Endothelial function | 12 weeks | Forearm post-ischemic flow mediated dilatation |
Countries
Sweden
Outcome results
None listed