Bone Tumors
Conditions
Keywords
Knee, Titanium Plate
Brief summary
Microwave ablation of bone tumors is time-consuming and usually results in postoperative fractures. Hence the investigators designed and fabricated a titanium plate customized to the patient's bone structures for fixation after the removal of tumorous tissue, to improve the clinical outcomes of microwave ablation.
Detailed description
3D models of tumor-bearing bone segments were constructed by using computed tomography (CT) and magnetic resonance imaging (MRI). The 3D models were used to design the model of personalized titanium plates. The model of the plates was transferred into a numerical control machine for manufacturing the personalized titanium plates by 3D printing technology. The plates were then surgically implanted for reconstruction assistance following microwave-induced hyperthermia to remove the bone tumor. Implementation parameters and knee function were then evaluated.
Interventions
PROCEDUREPersonalized titanium plate
3D models of tumor-bearing bone segments were constructed by using computed tomography (CT) and magnetic resonance imaging (MRI). The 3D models were used to design the model of personalized titanium plates. The model of the plates was transferred into a numerical control machine for manufacturing the personalized titanium plates by 3D printing technology. The plates were then surgically implanted for reconstruction assistance following microwave-induced hyperthermia to remove the bone tumor. Implementation parameters and knee function were then evaluated.
Sponsors
Medical Center of Assessment, Prevention and Treatment of Bone & Joint Diseases, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou General Hospital of Guangzhou Military Command
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
5 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Clinical diagnosis of primary malignant bone tumors in the distal femur or proximal tibia according to the preoperative biopsy. 2. Malignant soft tissue tumor invading distal femur or proximal tibia. 3. The patients have the opportunity of limb salvage and treatment of microwave-induced hyperthermia in situ and reconstruction with internal fixation.
Exclusion criteria
1. Distant metastasis. 2. Benign tumor. 3. Metastatic tumor around the knee. 4. No indication of limb salvage. 5. Malignant soft tissue tumor without bone invasion. 6. Recrudescent tumors.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The six degrees of freedom of the gait | An average of 29 months | including flexion/extension, adduction/abduction, internal/external rotation, anteroposterior translation, distal/lateral translation, medial/lateral translation |
| Musculoskeletal Tumor Society score | An average of 29 months | — |
| Mean maximum flexion of the knee | An average of 29 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean operation time | Time when the operation was begun |
Outcome results
None listed