Chronic Periodontitis, Renal Insufficiency Chronic
Conditions
Brief summary
The main aim and objective of this study was to evaluate the effects of Non- surgical periodontal therapy on the subgingival microbiota and biochemical parameters in patients with chronic kidney disease and chronic periodontitis.
Detailed description
The study was designed as a Non randomized prospective, interventional clinical trial. The sample size for the study was 40 individuals aged between 35-75 years, equally divided into two groups. Group I--- Patients with Chronic kidney disease and chronic periodontitis (Test) Group II--- Patients with Chronic periodontitis only (Controls) At baseline both the groups were analyzed for clinical, microbiological and also biochemical parameters and underwent Non-surgical Periodontal treatment (i.e. scaling and root planning). All parameters were reassessed again after 3 months. A total of 20 patients attending the outpatient wing of Hyderabad Kidney Centre , Malakpet,Hyderabad who were diagnosed clinically with Chronic Kidney disease and willing to participate in the study were included in the study. Another 20 patients attending the outpatient wing of Department of periodontics, Panineeya Mahavidyalaya Institute of Dental Sciences & Hospital, Hyderabad, diagnosed with Chronic Periodontitis and willing to participate in the study were taken. Biochemical parameters considered included -serum creatin & urinary albumin: creatin ratio. Microbiological assay was done by Polymerase chain reaction test (PCR) i.e., pooled plaque samples were taken from both predialysis as well as chronic periodontitis patients.
Interventions
OTHERScaling and Root planing
All the patients were asked to use a preprocedural mouthrinse and scaling and rootplaning was done using ultrasonic scalers.
Sponsors
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* A total of 20 patients diagnosed with Chronic kidney disease, (having abnormal Glomerular filtration rate(GFR) and serum Creatinine levels.) and chronic periodontitis (with at least 15 teeth remaining, and with the presence of ≥4 sites in 3 different teeth having clinical attachment loss (CAL) of ≥ 4mm and bleeding on probing). (Group I) * 20 patients diagnosed with chronic periodontitis only. (GroupII)
Exclusion criteria
* Patients with HIV infection, pregnancy, lupus erythematosus, rheumatoid arthritis, any systemic disorder, periodontal therapy in the preceding 6 months, or on any course of antibiotic prophylaxis for periodontal procedures were excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Levels of Microbiological and Biochemical Parameters | Change in levels of Microbiological and Biochemical parameters were assessed at baseline and 3 months after scaling and rootplaning | Microbiological assay was done by PCR test i.e., pooled plaque samples were taken from both predialysis as well as chronic periodontitis patients at baseline and 3 months after scaling and root planing. Supragingival plaque was removed carefully with a sterile scaler to prevent the contamination of the samples.Sample was harvested from the same site with a sterile Gracey curet 5-6 with one single vertical stroke on the root surface. Biochemical assay was done by Modified Jaffe's reaction to assess the levels of Serum Creatinine and urine samples were taken to assess the Albumin:Creatinine ratio |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical parameter -Gingival Index (GI) | Change in the GI was assessed at baseline and 3 months after Scaling and rootplaning | The Gingival index was assessed using a University of Carolina-15 (UNC-15) Probe. |
| Clinical Parameters-Probing depth(PD) and Clinical attachment levels (CAL) | Change in Pd was assessed at baseline and 3 months after scaling and rootplaning | The Pd was assessed using UNC-15 Probe |
| Clinical Parameter- Clinical attachment levels(CAL) | Change in CAL was assessed at baseline and 3 months after scaling and rootplaning | The CAL was assessed using UNC-15 Probe |
Outcome results
None listed