Liver Disease, Nutrition Disorders
Conditions
Brief summary
Malnutrition is prevalent among chronic liver disease patients. Inadequate ingestion and/or metabolic alterations modify the body composition and biological functions. The purpose of this study is to determine whether whey protein comsumption, due to amino acid profile, digestibility and bioactive compounds may be beneficial for patients waiting for liver transplantation
Detailed description
A randomized, double-blind, intervention study in which patients are randomly assigned to receive packages of 20g of whey protein (WP) or casein (CA) to take twice a day (20g in the morning and 20g at night), as a supplement, during 15 days. They are monitored weekly by calls. Regular usual diet is maintained. Patients underwent muscle functionality assessment by handgrip dynamometry and 6-min. walking test and, the inflammatory response by plasmatic cytokines. All tests are performed at the beginning and the end of intervention.
Interventions
DIETARY_SUPPLEMENTWhey protein
Patients, maintaining their regular usual diet, are submitted to a protein supplementation, during 15 days. They recieve 20g packages of whey protein or casein, to take twice a day: 20g in the morning and 20g at night.
Sponsors
Federal University of Minas Gerais
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Chronic liver disease, liver transplantation
Exclusion criteria
* Children, illiterate, elderly, renal failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nutritional status | Two years | Anthropometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate variability | Two years | Heart rate variability |
| Resting energy expenditure | Two years | Calorimetry |
Countries
Brazil
Outcome results
None listed