Acute Stroke
Conditions
Brief summary
Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance. The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.
Interventions
None listed
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \>= 18 years old * acute ischemic stroke secondary to a large vessel occlusion. * Patients hospitalized for endovascular therapy.
Exclusion criteria
* Pregnant or breast feeding patient * patient under legal protection * Patient opposition to participate in this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neutrophil counts | before recanalization | Plasma neutrophil activation bio-markers |
| neutrophil protease counts | before recanalization | — |
| recanalization score | immediately after endovascular procedure | Thrombolysis in Cerebral Infarction classification (TICI) |
| acute ischemic stroke etiology | within 24 hours after endovascular procedure | as defined by the Trial of Danaparoid (ORG10172) in Acute Stroke Treatment (TOAST classification) |
| severity of neurologic symptoms | baseline | National Institutes of Health Stroke Scale (NIHSS) |
| disruption of the blood-brain-barrier | within 24 hours after endovascular procedure | diagnosis on cerebral Computerized Tomography |
| brain haemorrhage | 24 hours after endovascular procedure | National Institutes of Health Stroke Scale (NIHSS) |
| Recovery of motor function after stroke | 3 months | modified Rankin scale |
| mortality | 3 months | — |
| adhesion molecules counts | before recanalization | — |
| free plasma DNA counts | before recanalization | — |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORJean-Philippe DESILLES, MD
Fondation OPH A de Rothschild
STUDY_CHAIRMikael MAZIGHI, MD, PhD
Fondation OPH A de Rothschild
Outcome results
None listed