Acute Myeloid Leukemia, Invasive Aspergillosis
Conditions
Brief summary
Patients with acute myeloid leukemia (AML) are at risk to develop severe infections whose invasive aspergillosis (IA). These infections are leading to an important morbidity and mortality. Antifungal prophylaxis is recommended by posaconazole for AML patients during neutropenia induced by induction chemotherapy. Their application is not uniform.
Detailed description
Invasive aspergillosis are frequent infections in hematological malignancy in particular during neutropenia induced by chemotherapy. Their incidence ranged between 5 to 25% according to the literature. Mortality may reach 30%. Our study described IA incidence in AML patients treated by intensive chemotherapy depending on antifungal prophylaxis by posaconazole. From 2009 to 2011, any patients received antifungal prophylaxis. From 2012 to 2015, patients received posaconazole during induction and salvage chemotherapy. During the all study period, efficacy of posaconazole is evaluated according to construction/demolition periods in hospital. All patients are hospitalized in High Efficiency Particulate Air (HEPA) filtration system.
Interventions
OTHERPatients without antifungal prophylaxis
Epidemiology data: clinical and biological informations collecting
DRUGPatients with antifungal prophylaxis
Hospitalized patients between 2012 and 2015 received Posaconazole prophylaxis during neutropenia period induced by induction or salvage chemotherapy.
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 18 years * acute myeloid leukemia * intensive chemotherapy (induction, consolidation, salvage, bone marrow transplantation)
Exclusion criteria
* \< 18 years * pregnancy * no intensive chemotherapy (palliative treatment, azacytidine...)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of invasive aspergillosis in acute myeloid leukemia | 1 year | Evaluation of annual incidence of invasive aspergillosis in acute myeloid leukemia treated by intensive chemotherapy between 2009 and 2015 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Efficiency of antifungal prophylaxis by posaconazole | 1 year | Comparison of two periods: 2009-2011 where patients had not antifungal prophylaxis and 2012-2015 where patients had antifungal prophylaxis by posaconazole during induction and salvage chemotherapy |
| Impact of antifungal prophylaxis by posaconazole about construction/demolition periods | 1 year | Comparison of incidence of invasive aspergillosis while antifungal prophylaxis and construction/demolition periods |
Countries
France
Outcome results
None listed