Infant, Newborn
Conditions
Keywords
pesticides, exposure, in utero
Brief summary
The MecoExpo project seeks to evaluate the in utero exposure of newborns in the Picardie region to commonly used pesticides. These pesticides were selected in a pilot study (the Mecopic study) on the basis of their toxicity (effects on foetal development, endocrine perturbation, neurological toxicity and carcinogenicity) and a certain number of indicators of pesticide use and the presence of pesticide in the environment in Picardie. These substances (or their metabolites) will be measured in the each newborn's meconium (the first faeces after birth) and each newborn's mother's hair in the Picardie region during the study period. The mother's exposure will also be assessed using a retrospective questionnaire (filled out within a few days of the delivery). Thus, the MecoExpo project will enable the investigators to: 1. evaluate the relationships between foetal exposure (via the meconium), maternal exposure (via the hair and the questionnaire) and clinical parameters measured at birth (term, length, weight, etc.). 2. map pesticide exposure across the Picardie region. 3. create a meconium bank in Picardie (the first ever meconium bank in France).
Interventions
OTHERmeconium
The meconium will be sampled in the first 2 days of life
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 2 Days
Healthy volunteers
No
Inclusion criteria
* All newborns in Picardie will be eligible. Good command of the French language by a least one of the two people with responsibility for the child will be required for filling out the questionnaire. * The mother's place of residence must have been in Picardie during the last two trimesters of pregnancy.
Exclusion criteria
* Newborns with foetal distress
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fœtal vs mother exposure - term | Day 2 | evaluate the relationships between foetal exposure (via the meconium), maternal exposure (via the hair and the questionnaire) and term at birth |
| fœtal vs mother exposure - length | Day 2 | evaluate the relationships between foetal exposure (via the meconium), maternal exposure (via the hair and the questionnaire) and length at birth |
| fœtal vs mother exposure - weight | Day 2 | evaluate the relationships between foetal exposure (via the meconium), maternal exposure (via the hair and the questionnaire) and weight at birth |
Countries
France
Outcome results
None listed