Infection, Sepsis, Septic Shock, Severe Sepsis
Conditions
Brief summary
The purpose of this study is to compare the effect of a short course antimicrobial therapy (5-days) versus a 10-days therapy on sepsis-related organ dysfunction.
Interventions
DRUGAntibiotic
Targeted antimicrobial therapy
Sponsors
Ospedale Santa Maria delle Croci
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients who received antibiotics for presumed infection
Exclusion criteria
* Prolonged therapy (eg, endocarditis) * Severe immunosuppression * Severe infections (due to viruses, parasites, or Mycobacterium tuberculosis) * Patients previously infected or colonized with multidrug resistant pathogens and moribund patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sepsis-related organ dysfunction | 14-days | Score used to track a person's status during the stay in an intensive care unit (ICU) to determine the extent of a person's organ function or rate of failure. The Sequential Organ Failure Assessment (SOFA) score numerically quantifies the number and severity of failed organs. Higher values represent worse outcome. A score of 0 is given for normal function through to 4 for most abnormal. The systems studied are: respiratory, coagulation, hepatic, cardiovascular, central nervous system, and renal. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital mortality | 30-days | In hospital mortality rate |
Countries
Italy
Contacts
Primary ContactVincenzo De Santis
Outcome results
None listed