IgG4-related Disease
Conditions
Brief summary
IgG4-related disease is a rare and very recently identified pathology, whose frequency is certainly underestimated. The clinical presentation varies among affected organs, and most often, patients have at least three organ damage. These organs exhibit tissue infiltration mononuclear polymorphic cells with often severe fibrosis progression resulting in a loss of function. The biomarker, though not specific, is a polyclonal elevated serum IgG4, and histological marker, currently held by several teams, is the presence within the inflammatory infiltrate, of a predominance of IgG4-expressing plasma-cells with a relative plasma-cells IgG4 + / IgG +\> 50% on tissue immunostaining. The investigators project provides a global assessment of T lymphocyte abnormalities and specifically the TFH (Follicular Helper) during this IgG4-related disease compared to so-called groups "control" subjects suffering from Sjogren syndrome or healthy subjects.
Interventions
BIOLOGICALextra blood draw samples
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* IgG4-related disease patients or * Sjogren syndrome patients or * Healthy subjects
Exclusion criteria
* Presence of autoimmune or inflammatory associated disease * Age less than 18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of Follicular Helper T cells (CD4 + CXCR5 + ICOShigh) in the blood | 36 months |
Countries
France
Contacts
STUDY_DIRECTORUrielle Desalbres
Assistance Publique Hôpitaux de Marseille
Outcome results
None listed