Sepsis
Conditions
Brief summary
Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.
Interventions
DRUG30 mg/kg amikacin or 8 mg/kg gentamicin
In order to improve the achievement of target peak concentrations, either 30 mg/kg amikacin or 8 mg/kg gentamicin was prescribed in ICU patients with severe sepsis. In combination with broad-spectrum antibiotics, according to the suspected pathogens and local clinical practice, 30 mg/kg amikacin or 8 mg/kg gentamicin was given (30 min intravenous infusion; the dosage ampoule was systematically emptied with a 5 ml flush). The peak serum concentration sampling occurred 30 minutes after the end of the infusion.
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ICU patient with severe sepsis * Treated with aminoglycosides
Exclusion criteria
* Renal replacement therapy * Allergy to aminoglycosides * Confirmed and/or suspected to have myasthenia * ICU-acquired neuromuscular disorder * Under guardianship * Prisoners * The patient has already participated in the present protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence/absence of target peak serum concentration of aminosides | 30 minutes after the end of the infusion. | Achievement of targeted peak serum concentration? |
Countries
France
Outcome results
None listed