Influence of Chronic Vascular Diseases on Transcranial Doppler Profiles in Critically Ill Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02898389

Acronym

CritiDop

Enrollment

Registered

2016-09-13

Start date

2016-06-14

Completion date

2018-09-14

Last updated

2020-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiration, Artificial, Sedated

Brief summary

The primary objective of this study is to show that cardiovascular risk factors associated with the chronic elevation of arterial resistance may be associated with false profiles of intracranial hypertension during transcranial doppler ultrasound of the middle cerebral arteries in intensive care unit patients. A false profile of intracranial hypertension is defined by a high pulsatility index without any intracranial pathology.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

for entry in the study: * Sedated patient under mechanical respiratory assistance Inclusion criteria for entry in group 1: the patient meets at least one of the following criteria: * The patient is a man over the age of 50 or a woman over the age of 60 * Hypercholesterolemia (LDL \> 1.6 g/L, HDL \< 0.4 g/L) * Arterial hypertension for over 10 years (treated or systolic arterial pressure \> 140 mmHG) * Type 2 diabetes for over 10 years * Active or former smoker in the past 3 years * History of cardiovascular event (peripheral artery disease, heart attack, stroke/transient ischemic attack over 3 months ago) * Chronic renal insufficiency with MDRD \< 30 ml/min/1.73m\^2 Inclusion criteria for entry in group 2: * The included patient is not in group 1

Exclusion criteria

* acute neurological disorder (brain trauma, infectious or immune meningitis, meningoencephalitis, ischemic or hemorrhagic stroke \<3 months) * pregnant woman * person under guardianship * prisoners * recent carotid surgery (\<1 month)

Design outcomes

Primary

Measure	Time frame
Pulsatility index on the middle cerebral arteries	Day 0
Diastolic velocity at the middle cerebral arteries	Day 0
Mean velocity at the middle cerebral arteries	Day 0

Countries

France

Outcome results