Attention Deficit and Disruptive Behavior Disorders, Feeding Behaviors, Lack of Satiety
Conditions
Keywords
ghrelin, breakfast meal, P-300
Brief summary
This study aims at assessing the effects of glucose and different types of breakfast on metabolic and neurofunctional responses in healthy individuals. Twelve healthy subjects, on a stable diet, in a randomized-crossover fashion, received either a 50 g glucose load (control) or one of these breakfast: B1: milk (125ml) and cereals (30g); B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g); B3: milk (125ml), bread (50g), apple (150g) and hazelnut cream chocolate (15g). Prior and upon completion of each tolerance test, an EEG was performed to measure frontal P300-evoked potentials.
Interventions
DIETARY_SUPPLEMENTGlucose
50g of glucose dissolved in 250 to 300ml of water was drunk. Prior and upon completion of each glucose tolerance test, an EEG was performed.
DIETARY_SUPPLEMENTMilk & Cereals
A breakfast (B1) including a glass of milk (125ml) and 30 g-corn flakes was consumed. Prior and upon completion of each tolerance test, an EEG was performed
DIETARY_SUPPLEMENTMilk, apple & snack
A breakfast (B2) including a glass of milk (220ml), an apple (200g), a cream chocolate filled sponge cake (30g) was consumed. Prior and upon completion of each meal tolerance test, an EEG was performed.
DIETARY_SUPPLEMENTMilk, apple & bread w/ cream
A breakfast (B3) including a glass of milk (125ml), an apple (150g), bread (50g, hazelnut chocolate cream (15g) was consumed. Prior and upon completion of each meal tolerance test, an EEG was performed.
DEVICEEEG_pre
Electroencephalography (EEG) was performed prior each tolerance test to assess frontal P300-evoked potentials
DEVICEEEG_post
Electroencephalography (EEG) was performed upon completion of each tolerance test to assess frontal P300-evoked potentials
Sponsors
Soremartec Italia S.r.l.
Ospedale San Donato
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 18.5 - 24.9 kg/m2 * normal glucose tolerance * stable diet
Exclusion criteria
* type 1 and type 2 diabetes * impaired glucose tolerance * dyslipidemia * metabolic syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of glucose vs different kind of breakfasts on cognitive performances via brain evoked-potentials measure | The incremental (post-pre) frontal P300 potential was assessed as a change ( before and 180 min after consumption) | On the same morning of the glucose tolerance test, before and 180 min after consumption, an EEG was performed to record P300 wave-evoked potentials. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of glucose vs different kind of breakfasts on AUC_glycemia in healthy subjects | Blood samples are drawn at -15, 0, 15, 30, 45, 60, 75, 90, 120 minutes with respect to the ingestion. | The incremental area under plasma glucose concentration curve (AUC\_glycemia) was used as summary measures of the metabolic responses resulting from the intake of either glucose or one of the 3 breakfasts. The incremental AUC was calculated as the difference between the total AUC and the product of the basal, pre-test concentration time during the experiment (i.e., 120 min). |
| Effect of glucose vs different kind of breakfasts on AUC_ghrelinemia in healthy subjects. | Blood samples are drawn at -15, 0, 15, 30, 45, 60, 75, 90, 120 minutes with respect to the ingestion. | The incremental area under plasma ghrelin concentration curve (AUC\_ghrelinemia) was used as summary measures of the metabolic responses resulting from the intake of either glucose or one of the 3 breakfasts. The incremental AUC was calculated as the difference between the total AUC and the product of the basal, pre-test concentration time during the experiment (i.e., 120 min). |
| Effect of glucose vs different kind of breakfasts on AUC_insulinemia in healthy subjects. | Blood samples are drawn at -15, 0, 15, 30, 45, 60, 75, 90, 120 minutes with respect to the ingestion. | The incremental area under plasma insulim concentration curve (AUC\_insulinemia) was used as summary measures of the metabolic responses resulting from the intake of either glucose or one of the 3 breakfasts. The incremental AUC was calculated as the difference between the total AUC and the product of the basal, pre-test concentration time during the experiment (i.e., 120 min). |
Countries
Italy
Outcome results
None listed