Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome

Neuronal Excitability of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN1) Channel Mutations in Dravet Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02896608

Acronym

EXCIDRAH

Enrollment

Registered

2016-09-12

Start date

2015-10-29

Completion date

2019-10-16

Last updated

2023-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dravet Syndrome

Brief summary

This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.

Interventions

DEVICEmeasure of neuronal excitability

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

15 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* early infantile epileptic encephalopathy with HCN1 channel mutation * control patients with no neurologic pathology (age, gender and body temperature matched) * epileptic patients (age, gender and body temperature matched)

Exclusion criteria

* pregnant or breast feeding patient

Design outcomes

Primary

Measure	Time frame
hyperpolarizing electrotonus	baseline
hyperpolarizing threshold current	baseline

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026