Uterine Cancer
Conditions
Brief summary
Surgical stress and anesthesia may cause immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. Dexmedetomidine has sympatholytic effect and preserves NK cell function. This study investigate the effect of dexmedetomidine on immune suppression and postoperative outcomes in patients undergoing uterine cancer resection.
Interventions
DRUGDexmedetomidine group
dexmedetomidine infusion (0.4 mcg/kg/h) from immediately after anesthetic induction to 24 h after surgery
DRUGControl group
0.9% saline infusion
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patient between 20 and 70 of age with ASA physical status Ⅰ-Ⅲ * patient scheduled for uterine cancer surgery
Exclusion criteria
* ASA physical status Ⅳ * severe hepatorenal disease * infection * metastasis to other organ * problem with communication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| natural killer cell cytotoxicity | 1 minute before surgery | Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| inflammatory response | 1 minute before surgery | inflammatory response is assessed by measuring levels of proinflammatory cytokines. |
Countries
South Korea
Outcome results
None listed