Renal Transplant
Conditions
Keywords
Kidney Transplant, Immunology
Brief summary
The investigators expect to better characterise B cell subpopulation and functional properties early after graft, to analyse effect of induction therapy (thymoglobulin versus basiliximab) on B cells, and to compare this B cell profiles with those obtained in our previous study in patients with chronic Antibody Mediated Rejection (cAMR)
Interventions
DRUGThymoglobulin Induction
The choice of the induction therapy is not a procedure of the study. This choice is made by the practioner, based on the graft recipient profile. This is a predefined group, the Thymoglobulin treatment is not an intervention in the study but must be considered as an exposure that is defined before the patient enters the study.
The choice of the induction therapy is not a procedure of the study. This choice is made by the practioner, based on the graft recipient profile. This is a predefined group, the Basiliximab treatment is not an intervention in the study but must be considered as an exposure that is defined before the patient enters the study.
Sponsors
University Hospital, Brest
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>18 years old * Recipient of a renal allograft * Patient receiving either basiliximab or thymoglobulin as in induction therapy for renal transplant * Patient presenting a low immunologic risk * Patient not opposed to his (her) study participation
Exclusion criteria
* Patient participating in a clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The distribution of mature blood B cells subpopulations will be compared between the 2 groups | one year after renal transplant |
| Proliferation of freshly isolated cells T in presence of autologous B cells will be compared between the 2 groups. | one year after renal transplant |
Secondary
| Measure | Time frame |
|---|---|
| Serum B-cell activating factor (BAFF) concentration comparison between the two groups | one year after renal transplant |
Countries
France
Contacts
STUDY_DIRECTORYannick Le meur
University Hospital, Brest
Outcome results
None listed