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Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years

Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02894047
Acronym
CASPER
Enrollment
42
Registered
2016-09-09
Start date
2013-07-31
Completion date
2015-10-31
Last updated
2016-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthritis, Rheumatoid

Keywords

calcium-sensitive receptor

Brief summary

Rheumatoid arthritis (RA) is the most frequent form of chronic inflammatory rheumatism in adults. The erosive damage influences the functional prognosis in patients with RA. At present, there are no sufficiently sensitive and specific predictive markers of erosive damage.

Interventions

BIOLOGICALblood

measurement of CaSR expression levels on synovial fluid monocytes

Sponsors

Centre Hospitalier Universitaire, Amiens
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients consulting in the Department of Rheumatology at Amiens University Hospital * Age ≥ 18 * RA meeting the 2010 ACR/EULAR criteria * Less than 2 years of RA progression * Effusion in at least 1 joint

Exclusion criteria

* Inability to give informed consent * Ongoing pregnancy * Previous treatment with an anti-osteoporosis medication * Intra-articular corticoid or hyaluronic acid injection in the previous 6 months * Coagulation disorders preventing arthrocentesis * Incarceration or legal guardianship

Design outcomes

Primary

MeasureTime frameDescription
CaSR expression rate level on synovial monocytes1 yearmeasured by flow cytometry

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026