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Time Prediction for Complete Recovery From Neuromuscular Blockade After Visual Recovery With Double Burst Stimulation

Time Prediction for Complete Recovery From Neuromuscular Blockade After Visual Recovery With Double Burst Stimulation

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02893436
Acronym
DBS PREDICTION
Enrollment
50
Registered
2016-09-08
Start date
2014-04-30
Completion date
2016-09-30
Last updated
2016-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Surgery

Brief summary

The purpose is to calculate the time for an optimal recovery (T4/T1 \> 0.9) from the moment when 2 responses to double burst stimulation are visually identical and this for 95% of patients.

Detailed description

Neuromuscular monitoring is a basic monitoring for all curarised patients. Acceleromiography is used to supervise neuromuscular blockade and allow measuring in an objective and quantitative manner the curarisation level during surgery and phase of recovery from neuromuscular blockade. Various parameters are usually measured during surgery: * T4/T1 ratio: ratio between the 4th and 1st response to train of four stimulation (TOF, 4 stimulations of 0.2 ms in 2 s). Neuromuscular recovery is considered appropriate if T4/T1 ratio is \> 0.9 * Double burst stimulation (DBS): 2 short tetanic stimulations separated by an interval of 750 ms. It is known that when DBSs induce the same visual and/or tactile response, T4/T1 recovery time is \> 0.6. However, for an optimal recovery, T4/T1 ratio must be \> 0.9. This study will analyze the interval between the moment when DBSs are visually identical and the T4/T1 ratio is \> 0.9, from anesthesia sheet of patients undergone surgery with tracheal intubation curarisation. Results will define a minimum time to have an optimal recovery after having visually identical DBS responses.

Interventions

PROCEDURESurgery with tracheal intubation curarisation

Sponsors

Central Hospital, Nancy, France
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* ASA score 1-3 * Needing a surgery with tracheal intubation curarisation

Exclusion criteria

* none

Design outcomes

Primary

MeasureTime frameDescription
Time interval between the moment when DBSs are visually identical and the T4/T1 ratio is > 0.9day 0measured with TOF-Watch Sx

Countries

France

Contacts

Primary ContactDenis Schmartz
d.schmartz@chru-nancu.fr

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026