Recurrent Corneal Erosion Syndrome
Conditions
Brief summary
Recurrent corneal erosion (RCE) syndrome can be observed either in the context of a dystrophy of the basement membrane or following corneal trauma. This syndrome is characterized by recurrent episodes of ocular pain more or less associated with localized separations between the outer epithelium and the epithelial basal lamina (basement membrane) because of anchorage abnormalities between these two corneal layers. This could be the result of an increased expression of metalloproteinases cleaving the hemidesmosomes which anchor epithelium to the basement membrane. The investigators hypothesis is that episodes of RCEs are favored by a hyper- expression of matricial metalloprotease 9 (MMP-9) induced by EMMPRIN and Galectin-3. The identification of such induction could lead to development of therapeutics inhibiting EMMPRIN and Galectin- 3 in the RCE syndrome.
Interventions
OTHERin vitro immuno-histo-chemical analysis of corneal epithelium
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years old * Recurrent Corneal Erosion Syndrome, with - failure of medical treatment and therapeutic photokeratectomy scheduled * Photorefractive surgical keratectomy (control patients)
Exclusion criteria
* Opposition to participation in the study * Known pregnancy or breast-feeding patient * No medical insurance coverage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| expression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) in epithelial cells | baseline |
Countries
France
Outcome results
None listed