Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years

Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years and Relationship Between Bone Loss and Adipokines.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02891356

Acronym

AMOS

Enrollment

180

Registered

2016-09-07

Start date

2013-07-31

Completion date

2022-12-31

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Nervosa, Osteoporosis

Keywords

Adiponectin, Bone remodelling markers

Brief summary

The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)

Interventions

DEVICEDEXA

The Dual Energy X-ray Absorptiometry (DEXA) is a third generation multi-captor DEXA device that allow short duration measurements. It measures Bone Mineral Density (BMD) at the spine and the femoral neck

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

* anorexia patient defined by DSM IV diagnostic criteria

Exclusion criteria

* patient with other psychiatric disease * patient with other a metabolic bone disease

Design outcomes

Primary

Measure	Time frame	Description
Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA)	4 years	measured the evolution of the bone mineral density in 180 anorexia nervosa patients and the relationship with this change and adipokine

Secondary

Measure	Time frame	Description
Incidence of osteoporotic fractures	at 2,4 and 6 years	—
Adiponectin plasma concentration by ELISA	at 2,4 and 6 years	measurement of circulating biological factors predicative of changes in BMD
Interleukin-7 plasma concentration by ELISA	at 2,4 and 6 years	measurement of circulating biological factors predicative of changes in BMD

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026