Blood Platelets, Bone Regeneration, Fibrin/Therapeutic Use, Molar, Third
Conditions
Keywords
platelet-rich fibrin, third molar, bone regeneration
Brief summary
The purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin.
Interventions
PROCEDUREPlatelet-rich fibrin
PROCEDUREControl group
Sponsors
Rio de Janeiro State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
16 Years to 29 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy patients * Preoperative platelet count higher than 150,00/ mm3 * Patient who required bilateral mandibular third molar extractions
Exclusion criteria
* Smokers patients * Alcoholics patients * Patients whom the inferior second molar was missing * Patients who had acute pericoronitis on the inferior third molar * Severe periodontal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in bone density through tomography evaluation | Change from Baseline bone measurement at three months after surgery |
Secondary
| Measure | Time frame |
|---|---|
| Change in periodontal-probing depth measurement on distal aspect of the second molar through Clinical evaluation | Change from baseline at 3 months after surgery |
| Pain through Visual Analogue Scale | 1st day after surgery |
| Soft tissue healing through Clinical evaluation numeric scale | 7th day after surgery |
Countries
Brazil
Outcome results
None listed