Infertility
Conditions
Keywords
Sildenafil Citrate, Induction of Ovulation, Pregnancy Rate
Brief summary
100 women with infertility classified into 2 groups. Group A: Included 50 women who will be given clomiphene citrate 50mg (clomid) orally 2 times/day from 2rd-7th day of the cycle and sildeaynafil citrate 20mg tab from 7th-11th day of the same cycle orally 3 times/day. Group B: Included 50 women who will be given clomiphene citrate 50mg (clomid) orally 2 times/day from 2rd-7th day of the cycle and placebo tablets from 7th-11th day of the same cycle orally 3 times/day.
Detailed description
100 women with infertility classified into 2 groups. Group A: Included 50 women who will be given clomiphene citrate 50mg (clomid) orally 2 times/day from 2rd-7th day of the cycle and sildeaynafil citrate 20mg tab from 7th-11th day of the same cycle orally 3 times/day. Group B: Included 50 women who will be given clomiphene citrate 50mg (clomid) orally 2 times/day from 2rd-7th day of the cycle and placebo tablets from 7th-11th day of the same cycle orally 3 times/day. Folliculometry was assessed by: * Transvaginal ultrasound: It was done on day 11th of the cycle to detect number of follicles and endometrial thickness. When the follicles reach ≥18 ml, injection of 5000 IU of HCG IM to trigger ovulation to both groups. Pregnancy was assessed by: * Beta HCG test: (Radioimmunoassay)
Interventions
DRUGClomiphene citrate
50mg (clomid,) orally 2 times/day from 2nd- 7th day of the cycle
DRUGsildenafil citrate
20mg tab from 7th-11th day of the same cycle orally 3times/day
DRUGPlacebo
tab from 7th-11th day of the same cycle orally 3times/day
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
1. Infertile women whether it's primary or secondary infertility 2. Woman's age: (18-35 years old) 3. Menstrual cycle from (24-35 days) 4. Normal semen analysis
Exclusion criteria
1. Age more than 35 years old 2. Ovarian cysts 3. Abnormal hormonal profile (e.g hyperprolactinaemia) 4. Significant cardiovascular disease 5. Serious liver disease or renal failure 6. Poorly controlled diabetes mellitus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy rate per cycle | 14 days after HCG triggering of ovulation | Serum pregnancy test |
Countries
Egypt
Contacts
Primary ContactAhmed Maged
Outcome results
None listed