Insulin Sensitivity
Conditions
Keywords
High-Intensity Sweeteners, Non-Nutritive Sweeteners, Artificial sweeteners, Glucose intolerance
Brief summary
This study will compare the effect of acute consumption of two carbonated drinks, sweetened with sugar or with non-caloric sweeteners, over the insulin response of healthy adults who normally consumed foods or drinks that contain non-caloric sweeteners
Detailed description
During the last decades there has been a sustained increase in prevalence of overweight and obesity and, along with it, of chronic noncommunicable diseases. There have been addressed various management strategies, including sugar replacement for Non-caloric Artificial Sweeteners (NAS). Nevertheless, in several cohort studies it has found the opposite effect, it has observed associations between the consumption of NAS with greater weight gain and increased risk of type 2 diabetes and metabolic syndrome. In clinical trials, in both humans and mice, there has been greater association with glucose intolerance, being 3 possible mechanisms: 1) dysbiosis of the intestinal microbiota; 2) altered regulation of appetite cephalic phase and secretion of glucagon like peptide-1 (GLP-1); and 3) increased intestinal glucose absorption via increased Sodium-Glucose Linked Transporter-1 (SGLT-1) and Glucose transporter 2 (GLUT2), transporters to glucose absorption. In the following review the major findings in the literature regarding the consumption of NAS and its deleterious effects on human health will be studied.
Interventions
DIETARY_SUPPLEMENTSugar sweetened beverages
350 cc (1 can) of sugar sweetened beverage
DIETARY_SUPPLEMENTArtificially sweetened beverages
350 cc (1 can) of artificially sweetened beverage
Sponsors
Instituto de Nutrición y Tecnología de los Alimentos
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Body Mass Index (BMI) between 18,5 - 24,9 kg/mt2 * Healthy men or women * Fasting plasma glucose \< 100 mg/dL
Exclusion criteria
* Consumption of drugs affecting glucose metabolism, antihypertensives or lipid lowering * Subjects with insulin resistance, type 1 or 2 diabetes, dyslipidemia, hypertension; heart, liver or kidney disease, respiratory failure, stroke, or any chronic illness. * Pregnant women. * Being treated to gain or lose weight. * History of recurrent episodes of acute diarrhea.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensibility | Measured at 6 intervals (3 times sugar sweetened beverages and 3 times artificially sweetened beverages), separated at least by 1 week from each other. All the tests must be assessed during 10 weeks utmost. | One insulinemic curve will be conducted to assess the effect of consumption of artificially sweetened beverage on insulin response compared to the consumption of a sugar sweetened drink. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic response | Measured at 6 intervals (3 times sugar sweetened beverages and 3 times artificially sweetened beverages), separated at least by 1 week from each other. All the tests must be assessed during 10 weeks utmost. | One glycemic curve will be conducted to assess the effect of consumption of artificially sweetened beverage on glycemic response compared to the consumption of a sugar sweetened drink. |
Countries
Chile
Contacts
Primary ContactRomina A Goza Ferreira, Magister c
Backup ContactSandra Hirsch Birn, Magister
Outcome results
None listed