Male Infertility
Conditions
Keywords
Docosahexanoic Acid,, DNA fragmentation, male fertility, Sperm parameters improvements
Brief summary
Sperm parameters will be examined before DHA (DHA=Docosahexanoic Acid) consumption, after one months and after 2 months taken Docosahexanoic Acid or placebo.
Detailed description
Prospective, randomized, double blind, placebo-controlled intervention study within individuals. Assisted reproduction unit and academic research laboratory. One hundred an eighty human semen samples from 60 infertile patients of IVI Sevilla clinic were finally included. Assessment of oxidative stress, apoptosis, lipid peroxidation, mitochondrial membrane potential, DNA fragmentation and standard sperm parameters before and after supplementation with different DHA doses (0.5, 1 and 2 g) or placebo for 1 and 3 months.
Interventions
DIETARY_SUPPLEMENTDHA
OTHERPlacebo
Sponsors
Vida Recoletas Sevilla
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* 1 year of infertility * \> 10 mill/ml of sperms * Motility \< 60% progressive * Morphology \< 2% (WHO 2010)
Exclusion criteria
No meeting the inclusion criteria.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sperm cell concentration | Three months | Measured in millions of sperm cells per ml of semen sample |
| Sperm cell motility | Three months | Measured in percentage of each type of motile sperm according to OMS 2010 criteria (A-D). |
| Sperm cell morphology | Three | Measured in percentage of sperm cell with normal morphology according to OMS 2010 criteria. |
Outcome results
None listed