Atopic Dermatitis
Conditions
Keywords
birth cohort, prenatal, skin barrier, atopic dermatitis, key nutritional factors
Brief summary
The study is a prospective birth cohort study and the purpose is to describe the status of maternal key nutrients(eg. folate and vitamin D) supplementation among pregnancies at early gestation in Shanghai, to find out the association between the level of serum key nutrients and atopic dermatitis (AD) in offsprings during 6 months.
Detailed description
This study based on Shanghai pregnancy population is a prospective birth cohort. The investigators obtain the data of participants' folic acid and vitamin D supplement intake through the questionnaire at 12-14 gestational weeks. And the investigators collect participants' blood samples during gestation to directly detect the biological exposure levels of folate and vitamin D. In the follow-up, skin barrier function is evaluated at time of infant 24-48 hours, 42 days and 6 months. During 6 months from birth, the incidence of AD is investigated on offsprings. This cohort study is aimed to (1) clarify the association between prenatal key nutrients with offspring AD; (2) assess the role of maternal key nutrients in the skin barrier of offsprings. It will be a good evidence for the AD prevention and a meaningful protocol to reduce the incidence of AD by its unique design.Univariate and multivariate association analyses will be performed to identify risk factors to AD by using multivariate logistic regression model.
Interventions
OTHERmaternal biological folate level
supplementation status and serum level
OTHERmaternal biological Vitamin D level
supplementation status and serum level
Sponsors
Children's Hospital of Fudan University
Minhang Maternal and Children Health Care Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Mother plans to proceed prenatal care and delivery in Minhang Maternal and Children Health Care Hospital * Offspring plans to stay in Shanghai until 6 months and proceed follow-up in Children's Hospital of Fudan University
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Infant atopic dermatitis | incident of AD during 6 months after birth, diagnosis confirmed based on disease history till 12 months | Disease diagnosis according to the criteria of Williams |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maternal RBC folate level | 12-14 gestational weeks | Whole blood sample collected will be used for evaluation |
| Maternal serum vitamin D level | 12-14 gestational weeks | Serum sample collected at different trimesters will be used for evaluation |
| Maternal serum folate level | 12-14 gestational weeks | Serum sample collected at different trimesters will be used for evaluation |
| Maternal folic acid supplement intake | 12-14 gestational weeks | Questionnaire survey will be used to obtain the data of maternal supplement intake |
| Maternal vitamin D supplement intake | 12-14 gestational weeks | Questionnaire survey will be used to obtain the data of maternal supplement intake |
| Infant skin barrier function (Transepidermal Water Loss, TEWL） | infant 24-48 hours | TEWL will be evaluated by the device of Multi Probe Adapter 4. |
| Infant atopic dermatitis incidence by 1year old | from birth , to 12months old | Disease diagnosis according to the criteria of Williams |
| Infant skin barrier function (Stratum corneum hydration, SCH) | infant 24-48 hours | SCH will be evaluated by the device of Multi Probe Adapter 4. |
| Infant skin barrier function (skin surface pH) | infant 24-48 hours | Skin pH will be evaluated by the device of Multi Probe Adapter 4. |
| Infant skin barrier function (sebum content) | infant 24-48 hours | Sebum content will be evaluated by the device of Multi Probe Adapter 4. |
| Maternal serum Vitamin E level | 12-14 gestational weeks | Serum sample collected at different trimesters will be used for evaluation |
| Maternal serum Vitamin A level | 12-14 gestational weeks | Serum sample collected at different trimesters will be used for evaluation |
| Child atopic dermatitis from 1 year old to 2 years old | from 1 year old to 2 years old | Disease diagnosis according to the criteria of Williams |
| Child atopic dermatitis from 2 years old to 5 years old | from 2 years old to 5 years old | Disease diagnosis according to the criteria of Williams |
| Maternal serum fatty acid level | 12-14 gestational weeks | Serum sample collected at different trimesters will be used for evaluation |
| Child atopic dermatitis from 5 years old to 8 years old | from 5 years old to 8 years old | Disease diagnosis according to the criteria of Williams |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORGuoying Huang, MD,PhD
Children's Hospital of Fudan University
Outcome results
None listed