Anterior Temporal Epilepsy, Anterior Temporal Lobectomy, Face Perception
Conditions
Brief summary
The purpose is to evaluate neuropsychological effects of anterior temporal epilepsy in face perception by comparison of performances of epileptic patients and control individuals, sex-, age- and socio-educational level-matched. Secondary purposes are to prospectively evaluate neuropsychological impact of anterior temporal lobectomy performed for surgical treatment of anterior temporal epilepsy on face perception (exploratory study).
Interventions
OTHERFace inversion effect test
OTHERMooney test
OTHERBenton Face Recognition test
OTHERFace composite effect test
OTHERCambridge Face Memory Test
OTHERMatching different view test
OTHERMemorizing and recognition of new faces test
OTHERMemorizing and recognition of new objects test
OTHERRecognition of celebrities and access to semantic information test
PROCEDURELobectomy
In patients with anterior temporal epilepsy, at 6 to 12 months after inclusion, depending on surgery decision taken after pre-surgery conventional intercritical assessment
Sponsors
Central Hospital, Nancy, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
ALL: * Informed consent * Affiliation to social security * Preliminary medical examination PATIENTS WITH EPILEPSY: * Symptomatic drug-resistant anterior temporal epilepsy (confirmed with video-electroencephalography and magnetic resonance imaging and if necessary intracerebral SEEG exploration) * Patient needing anterior temporal lobectomy and undergoing pre-surgery conventional intercritical assessment for surgery decision * Nonverbal IQ ≥ 70 (WAIS-IV) * At least 6 successful VOSP tests (perception test)
Exclusion criteria
ALL: * persons under legal protection or incapable to consent * Persons deprived of liberty by juridical or administrative decision PATIENTS WITH EPILEPSY: \- Sever visual disorders of neurological or ophthalmological origin CONTROL INDIVIDUALS: * Psychiatric or neurological disorders * Important ophthalmological disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals | day 0 |
Secondary
| Measure | Time frame |
|---|---|
| Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals) | day 0 and after 12 to 18 months |
Countries
France
Outcome results
None listed