The Bipolar Illness Onset Study (the BIO Study)

Conditions

Bipolar Disorder

Keywords

Bipolar disorder, Blood, Smartphone, Brain imaging, Cognition, Neuropsychology

Brief summary

This longitudinal study aims to identify 1) a composite blood-based biomarker, 2) a composite electronic Smartphone-based biomarker and 3) a neurocognitive signature for bipolar disorder

Detailed description

The study will include 300 patients with newly diagnosed/first episode bipolar disorder, 200 healthy siblings or child family members and 100 healthy individuals without a family history of affective disorder. All individuals will be investigated with repeated blood tests, Smartphone recordings, neuropsychological tests and brain imaging during a five to ten year study period.

Sharleny Stanislaus, Klara Coello, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Ida Seeberg et al. (11 authors)

Evidence-Based Mental Health2021-06-034 citations

10.1136/ebmental-2021-300259

Smartphone-based activity measurements in patients with newly diagnosed bipolar disorder, unaffected relatives and control individuals.

Stanislaus S, Vinberg M, Melbye S, Frost M, Busk J, Bardram JE, Kessing LV, Faurholt-Jepsen M.

2020-11-0216 citations

10.1186/s40345-020-00195-0

Daily self-reported and automatically generated smartphone-based sleep measurements in patients with newly diagnosed bipolar disorder, unaffected first-degree relatives and healthy control individuals

Sharleny Stanislaus, Maj Vinberg, Sigurd Melbye, Mads Frost, Jonas Busk et al. (8 authors)

Evidence-Based Mental Health2020-08-2414 citations

10.1136/ebmental-2020-300148

The Bipolar Illness Onset study: research protocol for the BIO cohort study

Lars Vedel Kessing, Klaus Munkholm, Maria Faurholt‐Jepsen, Kamilla Woznica Miskowiak, Lars Bo Nielsen et al. (19 authors)

BMJ Open2017-06-01155 citations

10.1136/bmjopen-2016-015462

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. Newly diagnosed/first episode bipolar patients, 2. First-generation relatives (siblings and children aged 15 to 40 years) to the recruited newly diagnosed/first episode bipolar patients. 3. Age- and gender matched sample of healthy individuals without a first-generation family history of effective disorders

Exclusion criteria

1. Significant physical disorders 2. Schizophrenia or related disorders

Design outcomes

Primary

Measure	Time frame
Composite blood based biomarker	5 years

Secondary

Measure	Time frame	Description
Composite smartphone based biomarker including self reported and smartphone generated data	5 years	Composite smartphone based biomarker including 1) self reported data and 2) smartphone generated data on physical activity 3) social activity and 4) voice features collected during phone calls
Composite neurocognitive marker including Cold and Hot cognition.	5 years	Composite neurocognitive marker including Cold cognition assessed with neuropsychological tests probing verbal memory and executive function and Hot cognition assessed with a comprehensive computerized battery of cognitive tests probing (i) emotional processing (ii) reward processing and (iii) emotional regulation.

Countries

Denmark

Outcome results