Schizophrenia
Conditions
Keywords
pitch discrimination, auditory processing disorders, auditory perception, auditory-verbal hallucinations, theory of mind
Brief summary
Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population worldwide. Although pathophysiology of this disease remains unclear, a growing interest is emerging for low-level sensory function, acknowledging that deficits in early stages of sensory processing are related to higher-order cognitive disturbances in schizophrenia. In the field of auditory processing, symptoms as auditory-hallucinations were found correlated with disabilities to discriminate psychoacoustic parameters of sounds.
Detailed description
Outcomes: Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test. The main objective is to assess this correlation. Our other objectives are to assess correlation between AHRS as well as other symptoms scales and psychoacoustic tests assessing intensity, length discrimination of non-verbal tones and self-monitoring abilities. Impact of therapeutic procedures (neuromodulation, psychotherapy) conducted independently of our study on these psychoacoustic tests will also be assessed. Methods: 30 subjects with schizophrenia will be included. Clinical and psychoacoustic measures will be carried out at J-0. In the case of patients receiving therapeutic procedures independently of our study, new clinical and psychoacoustic measures will be carried out at J+7 and J+30.
Interventions
OTHERClinical and psychoacoustic measures
Our study focuses on psychoacoustic tests, specialist care protocols (psychotherapy, neuromodulation ...) being made independently of our study, as part of medical activity of Cerletti care unit or differentiated protocols. Thus, our study shows no individual benefit for the patient. However, a better understanding of the neurophysiological mechanisms underlying auditory hallucinatory phenomenon could allow a better management of these patients in the near future
Sponsors
Hôpital le Vinatier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age from 18 to 65 years old * Meeting DSM-5.0 criteria for schizophrenia * Auditory Hallucinations Rating Scale ≥ 8 * Negative βHCG level if woman * Effective contraception if woman * Consent to be included in the study
Exclusion criteria
* Hearing impairment * Neurologic disorder * Other psychiatric disorder from the DSM-5.0 section II * Developed musical abilities (regular practice of singing or a musical instrument) * Pregnancy * Does not consent to be included in the study * Lacking in legal capacity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| percentage error in discrimination test psychoacoustic Tone Matching Task | immediately after treatment | Our main hypothesis is that Auditory Hallucinations Rating Scale (AHRS) scores are correlated with the percentage of wrong answers in a Tone-Matching Task test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Score the item hallucinations of psychometric ( positive and negative syndrome ) scale | immediately after treatment | Rating Scale(AHRS) as well as other symptoms scales and psychoacoustic tests assessing intensity, length discrimination of non-verbal tones and self-monitoring abilities. |
Countries
France
Outcome results
None listed