The Correlation Between the n-6:n-3 Ratio and Inflammatory Markers in Small for Gestational Age (SGA) Infants Compared With Appropriate for Gestational Age (AGA) Infants

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02887664

Enrollment

Registered

2016-09-02

Start date

2018-10-02

Completion date

2020-12-31

Last updated

2019-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appropriate for Gestational Age Infants, Small for Gestational Age Infants

Brief summary

Numerous studies have recommended the use of n-3 PUFA supplementation during human pregnancy and lactation for the prevention of preterm birth, beneficial effects on fetal development, visual and cognitive development and other functional outcomes of the infants. The aim of the present study is to assess the correlation between ratio of n-3:n-6 fatty acid and inflammation markers in SGA infants compared with appropriate for gestational age (AGA) infants. The investigators hypothesize that in SGA infants n-3 and n-6 fatty acid concentrations in cord blood will differ from those observed in AGA and might correlate with the level of circulating mediators.

Interventions

PROCEDUREBlood test

Blood will be drawn from mother's vein and from the cord to test for n-6:n-3 ratio and inflammatory markers: CRP, IL-6, TPO and TNF-alpha markers

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Mothers of SGA infants ( above 35 week of gestation) * Mothers of term and near-term AGA infants

Exclusion criteria

* Maternal chronic diseases, smoking, diabetes, alcohol use, pregnancy-associated hypertension and pre-eclampsia * Neonatal depression * Congenital malformations * Intrauterine infections * Chromosomal aberrations * Mothers interested in cord blood banking

Design outcomes

Primary

Measure	Time frame	Description
Cord blood analysis	at time of delivery	Determination of the cord blood values of inflammatory markers (CRP, IL-6, TPO, TNF-alpha) and of the n-6:n-3 ratio

Secondary

Measure	Time frame	Description
Maternal blood analysis	at time of delivery	Determination of the maternal blood values of inflammatory markers (CRP, IL-6, TPO, TNF-alpha) and of n-6:n-3 ratio

Countries

Israel

Contacts

Primary ContactDror Mandel, MD

drorm@tlvmc.gov.il+97236925690

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026