Circulating Platelet-monocyte Conjugates, Glioblastoma
Conditions
Keywords
platelet activation
Brief summary
Glioblastoma face an increased risk of venous or arterial thromboembolism. Furthermore, the most frequent immune cells in glioblastoma are tumor associated macrophages, which find theirself in an anti-inflammatory (M2) phenotype. Increased conjugates between circulating platelets and monocytes reflect an pro-inflammatory status.
Detailed description
Glioblastoma face an increased risk of venous or arterial thromboembolism. Furthermore, the most frequent immune cells in glioblastoma are tumor associated macrophages, which find theirself in an anti-inflammatory (M2) phenotype. Increased conjugates between circulating platelets and monocytes reflect an pro-inflammatory status.
Interventions
None listed
Sponsors
University Medicine Greifswald
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* MR-morphological suspicion for glioblastoma * informed consent
Exclusion criteria
* no informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean P-selectine expression in all platelets | 01/ 2016 - 10/ 2016 |
| Mean CD63 expression in all platelets | 01/ 2016 - 10/ 2016 |
| Mean CD40 Expression in all platelets | 01/ 2016 - 10/ 2016 |
| Mean platelet-monocyte-conjugate formation in the monocyte population | 01/ 2016 - 10/ 2016 |
Countries
Germany
Outcome results
None listed