Cerebrovascular Accident
Conditions
Brief summary
The purpose is to determine the relationship between anxiety and cognitive performances in patients with acute and chronic phases of cerebrovascular accident (CVA). Data from neuropsychological assessment concerning cognitive processes (working and episodic memory) sensitive to different dimensions of anxiety will be analyzed. The secondary purpose is to evaluate how some neurological (hemispherical lateralization of lesions), psychological (depression) and demographic (quality of life) variables can increase the effects of different dimensions of anxiety on cognitive processes, during the acute and/or chronic phase of CVA.
Detailed description
Data will be collected during usual neuropsychological evaluation and cerebral imagery examination (NIHSS, Rankin scale) of patients in acute (0-1 month) and chronic (6 months) phases of CVA.
Interventions
OTHERStandard neuropsychological assessment
OTHERBrain MRI
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Acute phase of carotid, vertebrobasilar or lacunar cerebrovascular accident with ischemic or hemorrhagic origin * Right-handed * Possible cooperation: understanding of French instructions * Normal or corrected vision * Normal or corrected hearing * Mini-mental state examination score higher than pathologic threshold according to age and sociocultural level of patient * Possible follow up of patient
Exclusion criteria
* Hearing problems * Vision problems * Right hemiplegia or acute monoparesis of right upper limb * Hemispatial neglect * Apraxia * Psychiatric or neurological history possibly interfering with neuropsychological evaluation * Important defect of working memory or executive functions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of verbal episodic memory with RL/RI 16 item test | 6 months (from CVA) |
| Evaluation of verbal working memory with Wechsler memory scale | up to 1 month (from CVA) |
| Evaluation of visuospatial working memory with Wechsler memory scale | up to 1 month (from CVA) |
| Evaluation of visual episodic memory with Rey and Taylor figure test | 6 months (from CVA) |
| State of anxiety evaluated with STAI-YA scale | up to 1 month (from CVA) |
| Anxiety proneness evaluated with STAI-YB scale | up to 1 month (from CVA) |
| Apprehension anxiety evaluated with Penn State Worry Questionnaire | up to 1 month (from CVA) |
| Evaluation of working memory updating with N-back verbal and visuospatial task | up to 1 month (from CVA) |
| Evaluation of working memory inhibition with Stimulus-response compatibility task | up to 1 month (from CVA) |
| Evaluation of working memory flexibility with Switching task | up to 1 month (from CVA) |
Secondary
| Measure | Time frame |
|---|---|
| Depression state evaluated with Back depression inventory | up to 1 month (from CVA) |
| Quality of life evaluated with SF-36 test | after 6 months from CVA |
| Hemispheric lateralization of lesions detected with MRI | up to 1 month from CVA |
Countries
France
Outcome results
None listed