Methodological Developments for Magnetic Resonance Imaging (MRI)

Développement Méthodologique de l'Imagerie Par Résonance Magnétique (IRM)

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02887053

Acronym

METHODO

Enrollment

1807

Registered

2016-09-01

Start date

2008-11-01

Completion date

2022-05-26

Last updated

2026-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Keywords

MRI, Healthy subjects

Brief summary

The purpose of this study is to optimize clinical MR protocols and to validate MR acquisition parameters.

Interventions

DEVICEMRI

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* to be over 18 year-old, * to be able to give an informed consent, * to have underwent a pre-inclusion medical examination, * to present no contraindication to MR examination, * to be enrolled in a social security plan.

Exclusion criteria

* subject refusal, * subject under a measure of legal protection, * any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ).

Design outcomes

Primary

Measure	Time frame	Description
Image quality based on standard imaging quality criteria	6 months after the last inclusion	Image quality criteria will be : * Signal to Noise Ratio and Contrast to Noise Ratio measured in arbitrary units. * absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale

Secondary

Measure	Time frame	Description
T1/T2 Quantitative sub studies	6 months after the last inclusion	For quantitative studies such as T1/T2 studies a T1/T2 quantification will be calculated. These parameters will be reported in ms.
Brain Functional MRI sub studies	6 months after the last inclusion	For functional MRI studies, brain activity will be described in terms of brain localisation based on blood oxygen level-dependent signal variation and its intensity.
Cardiac function MRI sub studies: volume	6 months after the last inclusion	For cardiac imaging, cardiac function will be evaluated. Parameters such as left ventricle (LV) and right ventricle (RV) end-diastolic volumes end-systolic volumes will be measured and reported in mL/m².
Cardiac mass MRI sub studies: mass	6 months after the last inclusion	For cardiac imaging, cardiac function will be evaluated. LV and RV mass index will be measured and reported in g/m2.
Cardiac function MRI sub studies: ejection fraction	6 months after the last inclusion	For cardiac imaging, cardiac function will be evaluated. Ejection fraction for both ventricles will be calculated and reported in %.
Diffusion weighted MRI sub studies	6 months after the last inclusion	For diffusion studies, the apparent diffusion coefficient (ADC) whic is a measure of the magnitude of diffusion (of water molecules) within tissue will be estimated (mm2/s).
Diffusion tensor MRI sub studies	6 months after the last inclusion	The fractional anisotropy (FA) which is a scalar value between zero and one, which describes the degree of anisotropy of a diffusion process, could also be estimated.

Countries

France

Contacts

PRINCIPAL_INVESTIGATORValérie Laurent, MD,PhD

CHRU de Nancy

PRINCIPAL_INVESTIGATORJacques Felblinger, MD,PhD