Renal Insufficiency, Chronic
Conditions
Keywords
Renal Insufficiency, Chronic, Diet, Protein-Restricted
Brief summary
The purpose of this study is to determine whether low protein diet and very low protein diet supplemented keto-/amino acid is effective in preventing the progression of chronic kidney disease (CKD , stage 2 to 5).
Detailed description
Dietary protein restriction represents a basic therapeutic approach in chronic kidney disease(CKD), by reducing the accumulation of nitrogen catabolic substances, and by delaying the progress of CKD and proteinuria, but the effects of the low protein diet on renal failure progression rate remain to be determined.The aim of this study is to evaluate the efficacy of low protein diet and α-keto acid tablet in retard the progress of CKD. This is a prospective study, 100 patients who meet inclusion and exclusion criteria will be included. The changes of glomerular filtration rate in CKD and time to renal replacement will be evaluated after 1 year treatment.
Interventions
BEHAVIORALlow protein diet plus α-keto acid
0.4-0.6g of proteins per kilo of body weight per day, supplemented with α-keto acid tablets
Sponsors
The Third Xiangya Hospital of Central South University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Patients with chronic kidney disease in stage 2 to 5 (GFR\<60 ml/min/1.73m2) receiving conservative treatment for CKD
Exclusion criteria
None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in glomerular filtration rate | 1 year | Nutritional status, evaluated by nutrition risk screening (NRS 2002), at the start and during the 1st year of investigators' intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Compliance to diet | 1 year | Compliance to diet, defined by the participants' persistence in low protein diet, by outpatient follow-up and telephone follow-up. |
| Nutritional status | 1 year | Nutritional status, evaluated by nutrition risk screening (NRS 2002), at the start and during the 1st year of investigators' intervention. |
Countries
China
Contacts
Primary ContactMin Liu, M.D.
Backup ContactMeng Wang, M.M.
Outcome results
None listed