The Association Between Autoimmune or Inflammation and Thyroid Disease

The Relationship of Vascular Cell Adhesion Molecule 1, C-reactive Protein, Brain-derived Neurotrophic Factor, Orexin and Depressive Symptoms in the Subjects With Thyroid Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02886949

Enrollment

500

Registered

2016-09-01

Start date

2011-11-30

Completion date

2024-12-31

Last updated

2020-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

THYROTOXICOSIS

Brief summary

This study aims to evaluate the effects of thyroid functions on energy homeostasis and inflammation.

Detailed description

The subjects were enrolled for evaluation of thyroid functions. The associations between thyroid function and energy homeostasis and inflammation will be assessed.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Subjects visits outpatient department due to a suspicion of thyroid disease

Exclusion criteria

* Psychological disorders, severe inflammatory or infection diseases.

Design outcomes

Primary

Measure	Time frame	Description
brain-derived neurotrophic factor	3 months	BDNF

Secondary

Measure	Time frame	Description
C-reactive protein (CRP)	3 months	Inflammation
Orexin	3 month	Psychological assessment
Zung Self-Rating Depression Scale (Zung SDS)	3 month	Depressive symptom
vascular cell adhesion molecule 1 (VCAM-1)	3 months	Inflammation
ankle brachial index (ABI)	3 months	Arterial stiffness
pulse wave velocity (PWV)	3 months	Arterial stiffness
mean arterial pressure (MAP)	3 months	Arterial stiffness
Body composition	3 month	fat component

Countries

Taiwan

Contacts

Primary ContactI-Te Lee, MD

itlee@vghtc.gov.tw

Outcome results