Epilepsy
Conditions
Keywords
Paediatrics, epilepsy surgery, genetic mutation, focal seizures
Brief summary
When focal epilepsies become drug-resistant, it could be eligible for cortical surgical resection. Therefore, an invasive EEG monitoring with depth electrodes is often needed during presurgical evaluation. Some of these children can have access to thermocoagulation inside the ictal onset zone, at the end of the monitoring and before to remove the electrodes. These thermocoagulations can disorganize the epileptogenic network thanks to millimetric cortical lesions around the electrodes. The aim is to stop or at least, to reduce the seizure frequency for few weeks or months. This could be a benefit for the child, and also a confirmation of the ictal onset zone and guide the surgeon. This technique is currently used in adult population for years, but remains very rare in children.
Interventions
PROCEDUREThermocoagulation
Thermocoagulation During pre-surgical Invasive EEG Monitoring
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Months to 17 Years
Healthy volunteers
No
Inclusion criteria
* age 18 month to 17 years old * focal drug-resistant epilepsy * small size lesion (1 or 2 gyri) or cryptogenic epilepsy * indication for EEG monitoring with depth electrodes during presurgical evaluation
Exclusion criteria
* formal contraindication to surgery or anaesthesia * functional area or potentially large epileptic area * refusal to participate in the study * no health insurance coverage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of children with a decrease of at least 50% of the seizure frequency | one month after surgery |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORMathilde CHIPAUX, MD
Fondation OPH A de Rothschild
Outcome results
None listed