Conventional Mechanical Ventilation and High Frequency Percussive Ventilation: Comparison of Their Effects on Alveolar Recruitment and Distension by CT-scan in Early ARDS Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02885584

Enrollment

Registered

2016-08-31

Start date

2013-12-31

Completion date

2017-05-31

Last updated

2016-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS

Keywords

Mechanical ventilation

Brief summary

High frequency percussive ventilation (HFPV) is a high frequency ventilation mode in which high frequency pulses accumulate to generate a low frequency tidal volume at a controlled airway pressure. Previous studies have suggested a protective effect of HFPV on lung injury. The goal of our study is to compare, in early ARDS patients, the effects of conventional mechanical ventilation and of high frequency percussive ventilation on alveolar recruitment and distension evaluated by CT-scan

Interventions

DEVICEHigh frequency percussive ventilation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient undergoing invasive ventilation for more than 24h * ARDS patient

Exclusion criteria

* Pneumothorax drained or not * Patient undergoing extracorporel mechanical oxygenation * Patient who had a pneumonectomy partiel or total

Design outcomes

Primary

Measure	Time frame
Percent of patients exhibiting under HFPV an increase of at least 15% of normally aerated end-expiratory lung volume	4 hours

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026