Role of Calcium Channels in Vascular Function

Role of T-type Calcium Channels in Vascular Function

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02885558

Enrollment

Registered

2016-08-31

Start date

2017-11-01

Completion date

2021-05-25

Last updated

2021-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelium, Vascular

Keywords

Receptors, Calcium Channel Blocker

Brief summary

The purpose of this study is to examine the role of T-type calcium channels in endothelial dysfunction observed with ageing.

Interventions

DRUGEfonidipine

8 weeks treatment with either efonidipine

DRUGNifedipine

8 weeks treatment with either nifedipine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* age 20 - 30 and 60-70 * BMI \< 30

Exclusion criteria

* Hypertension (\>150/90 mmHg) * Smoking * Physical activity \>2 hours/week * Known chronic diseases * Pregnancy or birth within 3 month * Alcohol misuse

Design outcomes

Primary

Measure	Time frame	Description
Vascular function	8 weeks	Hemodynamic response to femoral arterially infused vasoactive substances

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026