Parkinson Disease
Conditions
Keywords
Parkinson Disease, Pain, Deep Brain Stimulation, Laser-Evoked Potentials
Brief summary
Pain is a common symptom of Parkinson's disease (PD) but the physiology remains poorly understood. Recent work suggests that subthalamic nucleus deep brain stimulation (STN-DBS) could make a profit on the pain in PD. The investigator would drive a study with a follow up of PD patients before and after STN-DBS. The pain will be clinically explored by targeted questionnaires and electrophysiological through laser evoked potentials. The questionnaires are designed to quantify and characterize the pain in these patients. Laser evoked potentials will, through repetitive stimulation, study both the functional status of the afferent nociceptive pathways, their habituation to repetitive nociceptive stimuli, and so better understand any abnormalities of the central processing of nociceptive information.
Interventions
OTHERLaser-Evoked potential
Laser-Evoked potential can document lesions of spinothalamic tract and lateral brainstem and of thalamo-cortical projections conducting nociceptive signals. The rapid heating of skin by infrared laser pulses stimulate small fibers sensory pathways. The main cortical laser evoked potential is a complex of components N2-P2. Evaluation of the registered potentials includes shape, latency and amplitude.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* A patient with idiopathic Parkinson's disease * Age between 30 and 70 inclusive. * No cognitive decline (MMS greater than or equal to 24) * Normal brain MRI * Informed consent signed * With or without pain sensation
Exclusion criteria
* Presence of other neurological pathology that could explain the pain. * MMS less than 24 * Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Modification of habituation in percentage, between tests performed before and after DBS | After the second laser evoked potential which occurred around 3 months after STN-DBS | The habituation is the change of amplitude between the first and the second response of the double stimulation during the laser evoked potential. We calculated a percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in latency of laser evoked potential responses before and after DBS | After the second laser evoked potential which occurred around 3 months after STN-DBS | latency is calculated in millisecond |
| Change in amplitude of laser evoked potential responses before and after DBS | After the second laser evoked potential which occurred around 3 months after STN-DBS | amplitude is calculated in microvolts |
Countries
France
Outcome results
None listed